International Journal of Bioorganic and Medicinal Chemistry 2021-08-09T20:12:56+00:00 Dr. Suryakiran Navath, Ph. D., Open Journal Systems <p>Bridging Chemistry and Medicine: International Journal Bioorganic and Medicinal Chemistry (IJBC) by Sciforce Publications</p> <p>Embark on a journey that unites the worlds of chemistry and medicine, pioneering drug discovery, and scientific innovation with the International Journal Bioorganic and Medicinal Chemistry (IJBC), a prestigious publication by Sciforce Publications. IJBC serves as a guiding light for the latest research and innovations at the intersection of bioorganic chemistry and medicinal science, offering insights into the synthesis of bioactive compounds and their potential applications in healthcare. In this web content, we will explore the significance of IJBC, its contributions to the scientific community, and the captivating realm of bioorganic and medicinal chemistry.</p> A dual responsive probe based on bromo substituted salicylhydrazone moiety for the colorimetric detection of Cd2+ ions and fluorometric detection of F‒ ions: Applications in live cell imaging 2021-07-07T10:33:28+00:00 Krishnaveni Karuppiah Iniya Murugan Murugesan Sepperumal Siva Ayyanar <p>A new fluorimetric and colorimetric dual-mode probe, 4-bromo-2-(hydrazonomethyl) phenol (<strong>BHP</strong>) has been synthesized and successfully utilized for the recognition of Cd<sup>2+</sup>/F<sup>‒</sup> ions in DMSO/H<sub>2</sub>O (9:1, v/v) system. The probe displays dual channel of detection via fluorescence enhancement and colorimetric changes upon binding with F<sup>‒</sup> and Cd<sup>2+</sup> ions respectively. The Job’s plot analysis, ESI-MS studies, Density Functional Theoretical (DFT) calculations, <sup>1</sup>H NMR and <sup>19</sup>F NMR titration results were confirmed and highly supported the 1:1 binding stoichiometry of the probe was complexed with Cd<sup>2+</sup>/F<sup>‒</sup> ions. Furthermore, intracellular detection of F<sup>‒</sup> ions in HeLa cells and fluorescence imaging analysis in Zebrafish embryos results of the probe <strong>BHP</strong> might be used to reveal their potential applications in a biological living system.</p> <p> </p> 2021-02-17T00:00:00+00:00 Copyright (c) 2021 International Journal Bioorganic and Medicinal Chemistry Molecular Entities of Antimicrobial Drugsand Resistance Mechanism Underlying: Bioaccessibility, Bioavailability, and Bioaccumulation 2021-07-07T10:38:55+00:00 Rajiv Kumar <p>The three major groups of antifungal agents are there that are used in clinical use, azoles, polyenes, and allylamine/thiocarbamates, all own their antifungal activities to inhibit the reactivity of microbial or stop direct interaction of microbial with healthy cells.<sup>3</sup> Microbial organometallic assimilation, the bioaccessibility, bioavailability, and bioaccumulation properties of inorganic metals in different antimicrobial moieties that are interrelated and classified as abiotic (e.g., organic carbon) and biotic (e.g., uptake and metabolism).<sup>4</sup></p> 2021-06-25T00:00:00+00:00 Copyright (c) 2021 International Journal Bioorganic and Medicinal Chemistry The relatively higher concentrations of trace elements to arsenic may have influenced on methylation process of inorg- As in humans 2021-08-09T20:12:56+00:00 Uttam K Chowdhury <p>Trace elements (As, Se, Zn, Co, Cu, Pb, Cd, Ni, Mn, and Hg) were analyzed in blood as well as urine of arsenic exposed people in Mexico by using ICP-MS to know the influence of trace elements for biotransformation process of inorganic arsenic.</p> <p>The concentrations of Cu and Mn were significantly higher, and the concentrations of As, Zn, and Pb were significantly lower in blood for females compared to males. The correlations between the ratios of the concentrations of Se, Zn, Co, Cu, Pb, Cd, Ni, Mn, or Hg to As in blood as well as urine and urinary arsenic metabolites were stronger than the correlations found between the concentrations of above elements and urinary arsenic metabolites for both females and males. The concentrations of trace elements (for examples: Se, Mn, Hg, etc.) relative to As in urine and blood were positively correlated with urinary % inorg As as well as % MMA, and negatively correlated with % DMA as well as the ratios of % DMA to % MMA.</p> <p>On the other hand, due to low level of creatinine in urine, adjusted urinary trace elements concentrations express as µg/g cre were significantly higher than the unadjusted concentrations express as µg/L for the urine groups with arsenic concentrations ≤50 µg As/L. But there were no significant correlations observed between adjusted and unadjusted concentrations of trace elements for the urine groups with arsenic concentrations &gt;50 µg As/L. Adjusted urinary Se, Mn, and Hg concentrations were negatively and significantly associated with urinary creatinine for both females and males.</p> <p>The results of this study suggest that trace elements may have influenced for biotransformation process of inorganic arsenic in humans. The results also suggest that Se, Mn as well as Hg may decrease arsenic methylation with decreasing creatinine formation for both sexes, but it could be concentration dependent.</p> <p><strong>Abbreviation</strong>: SAM, S-adenosyl-L-methionine; SAHC, S-adenosyl-L-homocysteine.</p> 2021-07-16T00:00:00+00:00 Copyright (c) 2021 International Journal of Bioorganic and Medicinal Chemistry Revisit: The Synthesis of 3-amino pyrazoles promoted by p-toluenesulfonic acid as an efficient catalyst under solvent and solvent-free conditions 2021-07-17T17:32:48+00:00 Suryakiran Navath <p>An efficient and facile synthesis of <em>3-</em>amino pyrazoles has been described. The reaction of b-keto nitriles with hydrazines using <em>p-</em>toluenesulfonic acid as an efficient catalyst under solvent and solvent-free conditions afford corresponding <em>3-</em>amino pyrazoles in excellent yields</p> <p> </p> 2021-07-17T00:00:00+00:00 Copyright (c) 2021 International Journal of Bioorganic and Medicinal Chemistry Synthesis and structural elucidation of a series of isoflavones-based on FPR antagonists 2021-08-09T19:18:39+00:00 Eugenio Uriarte Fernanda Borges Alexandra Gaspar <div class="Section3"> <p>Isoflavones are naturally occurring compounds well-known for their beneficial role in several diseases, such as cancer and inflammation. Recently some isoflavones derivatives were reported as potent and competitive antagonists of formyl peptide receptors (FPRs) with an important role in regulating the inflammatory process. As a result of their biological activities, there is a huge interest in developing synthetic procedures to obtain isoflavones. Surprisingly, and as far as our knowledge goes, the synthetic work and full characterisation of the isoflavones described as FPR antagonists weren’t yet reported. The work herein described comprises the synthesis of two series of 2-trifluoromethyl isoflavones, including the ones described as FPR antagonists and their complete characterisation by 1D, 2D NMR techniques and high-resolution mass spectroscopy.</p> </div> 2021-02-25T00:00:00+00:00 Copyright (c) 2021 International Journal Bioorganic and Medicinal Chemistry